Adjustable sling for the treatment of post-prostatectomy urinary incontinence: systematic review and meta-analysis.

Urinary incontinence after prostatectomy has a significant negative impact on the quality of life of the patient. The surgical treatment includes several models of male slings, such as adjustable slings. The objective of this study was to evaluate the effectiveness and safety of adjustable sling in the treatment of post-prostatectomy urinary incontinence. This is a systematic review of literature. The following electronic databases were searched until January 2018: PubMed®, Embase, CENTRAL and LILACS. The keywords used in the search strategies were: "prostatectomy" [Mesh], "urinary incontinence" [Mesh] and "suburethral slings" [Mesh]. Randomized clinical trials and observational studies, with or without Control Group, and follow-up of more than 12 months were included. Only one randomized study with high risk of bias was included and it concluded the effectiveness equivalence between adjustable and non-adjustable slings. All other studies were cases series with patients of varying levels of incontinence intensity and history of pelvic radiation therapy and previous surgeries. The meta-analysis for 0 pad in 24 hours demonstrated an effectiveness of 53%. For the 0 to 1 pad test in 24 hours, the meta-analysis resulted in an effectiveness of 69%. Risk factors for surgery failure include prior radiation, severity of post-prostatectomy urinary incontinence, and previous surgeries. The meta-analysis of the extrusion rate was 9.8% and the most commonly reported adverse effects were pain and local infection. Evidence of low quality indicates that adjustable slings are effective for treating post-prostatectomy urinary incontinence, with frequency of adverse events similar to the surgical option considered gold standard (the artificial urinary sphincter implant).

Adjustable sling for the treatment of post-prostatectomy urinary incontinence: systematic review and meta-analysis / Implante de sling ajustável no tratamento da incontinência urinária pós-prostatectomia: revisão sistemática e meta-análise

ABSTRACT Urinary incontinence after prostatectomy has a significant negative impact on the quality of life of the patient. The surgical treatment includes several models of male slings, such as adjustable slings. The objective of this study was to evaluate the effectiveness and safety of adjustable sling in the treatment of post-prostatectomy urinary incontinence. This is a systematic review of literature. The following electronic databases were searched until January 2018: PubMed®, Embase, CENTRAL and LILACS. The keywords used in the search strategies were: "prostatectomy" [Mesh], "urinary incontinence" [Mesh] and "suburethral slings" [Mesh]. Randomized clinical trials and observational studies, with or without Control Group, and follow-up of more than 12 months were included. Only one randomized study with high risk of bias was included and it concluded the effectiveness equivalence between adjustable and non-adjustable slings. All other studies were cases series with patients of varying levels of incontinence intensity and history of pelvic radiation therapy and previous surgeries. The meta-analysis for 0 pad in 24 hours demonstrated an effectiveness of 53%. For the 0 to 1 pad test in 24 hours, the meta-analysis resulted in an effectiveness of 69%. Risk factors for surgery failure include prior radiation, severity of post-prostatectomy urinary incontinence, and previous surgeries. The meta-analysis of the extrusion rate was 9.8% and the most commonly reported adverse effects were pain and local infection. Evidence of low quality indicates that adjustable slings are effective for treating post-prostatectomy urinary incontinence, with frequency of adverse events similar to the surgical option considered gold standard (the artificial urinary sphincter implant).

RESUMO A incontinência urinária pós-prostatectomia tem importante impacto negativo na qualidade de vida do portador. O tratamento cirúrgico inclui slings masculinos e, entre os diversos modelos, os slings ajustáveis. O objetivo deste estudo foi avaliar a efetividade e a segurança do sling ajustável no tratamento da incontinência urinária pós-prostatectomia. Trata-se de revisão sistemática de literatura. Foram pesquisadas as seguintes bases de dados eletrônicas até janeiro de 2018: PubMed®, Embase, CENTRAL e LILACS. As palavras-chaves utilizadas nas estratégias de busca foram: "prostatectomy" [Mesh], "urinary incontinence" [Mesh] e "suburethral slings" [Mesh]. Foram incluídos ensaios clínicos randomizados e estudos observacionais controlados ou não com seguimento maior que 12 meses. Apenas um estudo randomizado com alto risco de viés foi localizado e concluiu a equivalência de efetividade de slings ajustáveis e não ajustáveis. Todos os outros estudos foram série de casos com pacientes de variados níveis de intensidade da incontinência e histórico de radioterapia pélvica e cirurgias prévias. A metanálise para 0 pad em 24 horas demonstrou efetividade de 53%. Para o desfecho 0 a 1 pad em 24 horas, a metanálise resultou em efetividade de 69%. Os fatores de risco para insucesso da cirurgia incluem radiação prévia, gravidade da incontinência urinária pós-prostatectomia e cirurgias anteriores. A metanálise da taxa de extrusão foi de 9,8%, e os efeitos adversos mais relatados foram dor e infecção local. Evidências de baixa qualidade indicam que os slings ajustáveis são efetivos para o tratamento da incontinência urinária pós-prostatectomia, com frequência de eventos adversos semelhantes à opção cirúrgica considerada padrão-ouro (o implante de esfíncter urinário artificial).

Immediate versus delayed treatment for recently symptomatic carotid artery stenosis

ABSTRACT BACKGROUND: The timing of surgery for recently symptomatic carotid artery stenosis remains controversial. Early cerebral revascularization may prevent a disabling or fatal ischemic recurrence, but it may also increase the risk of hemorrhagic transformation, or of dislodging a thrombus. This review examined the randomized controlled evidence that addressed whether the increased risk of recurrent events outweighed the increased benefit of an earlier intervention. OBJECTIVES: To assess the risks and benefits of performing very early cerebral revascularization (within two days) compared with delayed treatment (after two days) for people with recently symptomatic carotid artery stenosis. METHODS: Search methods: We searched the Cochrane Stroke Group Trials Register in January 2016, the Cochrane Central Register of Controlled Trials (CENTRAL; The Cochrane Library 2016, issue 1), MEDLINE (1948 to 26 January 2016), EMBASE (1974 to 26 January 2016), LILACS (1982 to 26 January 2016), and trial registers (from inception to 26 January 2016). We also handsearched conference proceedings and journals, and searched reference lists. There were no language restrictions. We contacted colleagues and pharmaceutical companies to identify further studies and unpublished trials Selection criteria: All completed, truly randomized trials (RCT) that compared very early cerebral revascularization (within two days) with delayed treatment (after two days) for people with recently symptomatic carotid artery stenosis. Data collection and analysis: We independently selected trials for inclusion according to the above criteria, assessed risk of bias for each trial, and performed data extraction. We utilized an intention-to-treat analysis strategy. MAIN RESULTS: We identified one RCT that involved 40 participants, and addressed the timing of surgery for people with recently symptomatic carotid artery stenosis. It compared very early surgery with surgery performed after 14 days of the last symptomatic event. The overall quality of the evidence was very low, due to the small number of participants from only one trial, and missing outcome data. We found no statistically significant difference between the effects of very early or delayed surgery in reducing the combined risk of stroke and death within 30 days of surgery (risk ratio (RR) 3.32; confidence interval (CI) 0.38 to 29.23; very low-quality evidence), or the combined risk of perioperative death and stroke (RR 0.47; CI 0.14 to 1.58; very low-quality evidence). To date, no results are available to confirm the optimal timing for surgery. AUTHORS CONCLUSIONS: There is currently no high-quality evidence available to support either very early or delayed cerebral revascularization after a recent ischemic stroke. Hence, further randomized trials to identify which patients should undergo very urgent revascularization are needed. Future studies should stratify participants by age group, sex, grade of ischemia, and degree of stenosis. Currently, there is one ongoing RCT that is examining the timing of cerebral revascularization.

Immediate versus delayed treatment for recently symptomatic carotid artery stenosis.

BACKGROUND:: The timing of surgery for recently symptomatic carotid artery stenosis remains controversial. Early cerebral revascularization may prevent a disabling or fatal ischemic recurrence, but it may also increase the risk of hemorrhagic transformation, or of dislodging a thrombus. This review examined the randomized controlled evidence that addressed whether the increased risk of recurrent events outweighed the increased benefit of an earlier intervention. OBJECTIVES:: To assess the risks and benefits of performing very early cerebral revascularization (within two days) compared with delayed treatment (after two days) for people with recently symptomatic carotid artery stenosis. METHODS:: Search methods: We searched the Cochrane Stroke Group Trials Register in January 2016, the Cochrane Central Register of Controlled Trials (CENTRAL; The Cochrane Library 2016, issue 1), MEDLINE (1948 to 26 January 2016), EMBASE (1974 to 26 January 2016), LILACS (1982 to 26 January 2016), and trial registers (from inception to 26 January 2016). We also handsearched conference proceedings and journals, and searched reference lists. There were no language restrictions. We contacted colleagues and pharmaceutical companies to identify further studies and unpublished trials Selection criteria: All completed, truly randomized trials (RCT) that compared very early cerebral revascularization (within two days) with delayed treatment (after two days) for people with recently symptomatic carotid artery stenosis.Data collection and analysis: We independently selected trials for inclusion according to the above criteria, assessed risk of bias for each trial, and performed data extraction. We utilized an intention-to-treat analysis strategy. MAIN RESULTS:: We identified one RCT that involved 40 participants, and addressed the timing of surgery for people with recently symptomatic carotid artery stenosis. It compared very early surgery with surgery performed after 14 days of the last symptomatic event. The overall quality of the evidence was very low, due to the small number of participants from only one trial, and missing outcome data. We found no statistically significant difference between the effects of very early or delayed surgery in reducing the combined risk of stroke and death within 30 days of surgery (risk ratio (RR) 3.32; confidence interval (CI) 0.38 to 29.23; very low-quality evidence), or the combined risk of perioperative death and stroke (RR 0.47; CI 0.14 to 1.58; very low-quality evidence). To date, no results are available to confirm the optimal timing for surgery. AUTHORS CONCLUSIONS:: There is currently no high-quality evidence available to support either very early or delayed cerebral revascularization after a recent ischemic stroke. Hence, further randomized trials to identify which patients should undergo very urgent revascularization are needed. Future studies should stratify participants by age group, sex, grade of ischemia, and degree of stenosis. Currently, there is one ongoing RCT that is examining the timing of cerebral revascularization.

Perioperative corticosteroids for preventing complications following facial plastic surgery

BACKGROUND: Early recovery is an important factor for people undergoing facial plastic. However, the normal inflammatory processes that are a consequence of surgery commonly cause oedema (swelling) and ecchymosis (bruising), which are undesirable complications. Severe oedema and ecchymosis delay full recovery, and may make patients dissatisfied with procedures. Perioperative corticosteroids have been used in facial plastic surgery with the aim of preventing oedema and ecchymosis. OBJECTIVES: To determine the effects, including safety, of perioperative administration of corticosteroids for preventing complications following facial plastic surgery in adults. METHODS: Search strategy: In January 2014, we searched the following electronic databases: the Cochrane Wounds Group Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library); Ovid MEDLINE; Ovid MEDLINE (In-Process & Other Non-Indexed Citations); Ovid Embase; EBSCO CINAHL; and Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS). There were no restrictions on the basis of date or language of publication. Selection criteria: We included RCTs that compared the administration of perioperative systemic corticosteroids with another intervention, no intervention or placebo in facial plastic surgery. ata collection and analysis: Two review authors independently screened the trials for inclusion in the review, appraised trial quality and extracted data. MAIN RESULTS: We included 10 trials, with a total of 422 participants, that addressed two of the outcomes of interest to this review: swelling (oedema) and bruising (ecchymosis). Nine studies on rhinoplasty used a variety of different types, and doses, of corticosteroids. Overall, the results of the included studies showed that there is some evidence that perioperative administration of corticosteroids decreases formation of oedema over the first two postoperative ...

Cianoacrilato como uma nova abordagem para a hipersensibilidade dentinária - um ensaio clínico-piloto / Cyanoacrylate as a new approach to dentin hypersensitivity - a pilot clinical trial

Este estudo teve como objetivo avaliar a efetividade clínica do cianoacrilato (Super Bonder) na redução da hipersensibilidade dentinária, quando comparado com o uso de laser de baixa intensidade. Foi adotado um desenho boca dividida em 11 pacientes, nos quais 17 hemiarcos foram tratados com laser e 17 foram tratados com cianoacrilato. Os tratamentos foram realizados em três sessões, com intervalos de 48 horas. A dor foi avaliada por um único examinador calibrado e cego, através de uma Escala de Avaliação Numérica (EAN), em quatro momentos diferentes: baseline e após o tratamento, em intervalos de 24 horas (T1), 30 dias (T2) e 120 dias (T3). O maior valor da EAN em cada quadrante foi considerado para análise estatística. Uma redução significativa na sensibilidade foi encontrada em 24 horas (p=0,001) com o tratamento com cianoacrilato; aos 120 dias (p=0,001), a sensibilidade foi estatisticamente menor para o grupo tratado com laser, quando o estímulo usado foi o Endo-Ice. Com estímulo evaporativo, o grupo tratado com cianoacrilato demonstrou sensibilidade estatisticamente menor aos 120 dias (p=0,010). Concluiu-se que o cianoacrilato pode fornecer uma alternativa de fácil acesso e viável para o tratamento da sensibilidade dentária, quando comparado à laserterapia.

Access to health information on the internet: a public health issue?

OBJECTIVE: To progress in the understanding of the user profile and of search trends for health information on the internet. METHODS: Analyses were performed based on 1,828 individuals who completed an electronic questionnaire available on a very popular health website. At the same time, through the "elite survey" method, 20 specialists were interviewed, aiming at assessing quality control strategies regarding health information disseminated online. RESULTS: A predominance of female users who research information for themselves (= 90%), who consider the internet one of their main sources of health information (86%), and who spend from 5 to 35 hours online every week (62%) was verified. High reliability is assigned to information from specialists (76%), and low reliability to television, radio, or blogs (14%). CONCLUSION: It can be concluded that the internet is proving to be a major source of health information for the population, and that website certification is a strategy to be contemplated to improve the quality of information and to promote public health.

Acesso a informações de saúde na internet: uma questão de saúde pública? / Access to health information on the internet: a public health issue?

OBJETIVO: Avançar no entendimento sobre o perfil do usuário e as tendências de busca por informações de saúde na internet. MÉTODOS: As análises foram feitas a partir de 1.828 indivíduos que responderam a um questionário eletrônico disponibilizado em um portal de saúde de grande acesso. Paralelamente, por meio do método de "survey de elites", 20 especialistas foram entrevistados para avaliar estratégias de controle de qualidade das informações de saúde veiculadas na rede. RESULTADOS: Verificou-se o predomínio de usuários do gênero feminino que buscam informações para própria saúde(= 90%), que consideram a internet uma de suas principais fontes de informação em saúde (86%) e passam de 5 a 35 horas na web por semana (62%). Atribui-se alta confiança às informações vindas de especialistas (76%) e baixa confiança na televisão, rádio ou blogs (14%). CONCLUSãO: Conclui-se que a internet tem-se mostrado uma fonte de informação em saúde de grande relevância para população e que a certificação de sites é uma estratégia a ser considerada, na perspectiva de melhoria da qualidade das informações e promoção da saúde pública.

OBJECTIVE: To progress in the understanding of the user profile and of search trends for health information on the internet. METHODS: Analyses were performed based on 1,828 individuals who completed an electronic questionnaire available on a very popular health website. At the same time, through the "elite survey" method, 20 specialists were interviewed, aiming at assessing quality control strategies regarding health information disseminated online. RESULTS: A predominance of female users who research information for themselves (= 90%), who consider the internet one of their main sources of health information (86%), and who spend from 5 to 35 hours online every week (62%) was verified. High reliability is assigned to information from specialists (76%), and low reliability to television, radio, or blogs (14%). CONCLUSION: It can be concluded that the internet is proving to be a major source of health information for the population, and that website certification is a strategy to be contemplated to improve the quality of information and to promote public health.

Biological, behavioral, and socioeconomic factors associated with death from AIDS in Brasília, Brazil, in 2007 / Fatores biológicos, comportamentais e socioeconômicos associados ao óbito por AIDS em Brasília, Brasil, em 2007

INTRODUCTION: In the jurisdiction of Brasília, Brazil, significant reductions in mortality rates and lethality resulting from acquired immunodeficiency syndrome (AIDS) were observed shortly after the introduction of highly active antiretroviral therapy. In recent years, however, the decline of these rates has not been as significant. Non-adherence to treatment and delayed diagnosis appear to be the main factors that increase the risk of death from AIDS. Behavioral, socioeconomic, and biological factors could also be associated with increased risk of death due to AIDS. This study aimed to identify which of these factors were associated with deaths from AIDS in Brasília. METHODS: A case-control study was undertaken using the data recorded in the Information System of Notifiable Diseases. Cases consisted of AIDS deaths occurring in 2007, residing in Brasília, and over 12 years of age. Controls consisted of AIDS patients who did not die until December 31 2007, also residing in Brasília, and over 12 years of age. For each group, frequency and proportion tables for the variables were prepared. The statistical association of each factor in isolation with the occurrence of the deaths was verified through a model of multivariate analysis using logistic regression. RESULTS: The factors that were associated with an increased risk of death were intravenous drug use, age 50 years or more, and residing in a region whose residents have low per capita income. CONCLUSIONS: We identified factors associated with death due to AIDS that can guide health planning.

INTRODUÇÃO: No Distrito Federal, Brasil, houve importante redução das taxas de mortalidade e de letalidade por AIDS logo após a introdução da terapia antirretroviral altamente ativa, mas nos últimos anos o declínio dessas taxas não foi significativo. Não adesão ao tratamento e diagnóstico tardio parecem ser os principais fatores que elevam o risco de óbito por AIDS. Fatores comportamentais, socioeconômicos e biológicos também podem estar associados ao maior risco de óbito por AIDS. O objetivo deste estudo foi identificar quais desses fatores apresentaram associação com os óbitos por AIDS no Distrito Federal. MÉTODOS: Estudo do tipo caso-controle, utilizando os dados registrados no Sistema de Informação de Agravos de Notificação, em que foram considerados casos os óbitos por AIDS ocorridos em 2007, residentes no Distrito Federal e maiores de 12 anos de idade e, controles os doentes de AIDS que não foram a óbito até 31 de dezembro de 2007, também residentes no Distrito Federal e com mais de 12 anos de idade. Prepararam-se, para cada grupo, tabelas de frequência e proporção para as variáveis. Foi verificada a associação estatística de cada fator isoladamente com a ocorrência dos óbitos e também por meio de um modelo de análise multivariável por regressão logística. RESULTADOS: Os fatores que apresentaram associação com maior risco de óbito foram: usar drogas injetáveis, ter idade maior ou igual a 50 anos e residir em local cujos moradores possuem baixa renda per capita. CONCLUSÕES: Identificaram-se fatores associados ao óbito por AIDS que poderão nortear o planejamento em saúde.

Blood pressure control in hypertensive patients within Family Health Program versus at Primary Healthcare Units: analytical cross-sectional study.

CONTEXT AND OBJECTIVE: Hypertension is a public health problem due to its high prevalence and long-term cardiovascular complications. In Brazil in 2005, cardiovascular diseases were responsible for 28% of all deaths. Efforts are being made within primary care to achieve adequate hypertension control. The Family Health Program (FHP) has the aims of promoting quality of life and intervening in factors that put this at risk. The objective of this study was to evaluate the rate of blood pressure control among patients followed up at FHP units compared with those at primary healthcare units (PHUs). DESIGN AND SETTING: Analytical cross-sectional study in the municipality of Petrópolis, Rio de Janeiro, from January to December 2005. METHODS: Five hundred patients with a diagnosis of hypertension were included: 250 were being followed up at two FHP units and 250 at two PHUs. The diagnosis of hypertension was based on the Fourth Brazilian Hypertension Consensus, and the patients needed to have been under follow-up at the units for at least 12 months. Patients' blood pressure was considered to be under control if it was less than 140/90 mmHg at the last consultation. RESULTS: Blood pressure was under control in 29.2% (n = 73) at FHP units and 39.23% (n = 98) at PHUs (odds ratio = 0.64; confidence interval = 0.44-0.93; P = 0.024). CONCLUSION: Blood pressure control was better among patients followed up at PHUs than among those followed up at FHP units.

Saúde da criança: fatores de risco aplicados em programas de atenção básica à saúde / Child health: risk factors applied in programs of primary health care

OBJETIVO: comparar as frequências dos fatores de risco em crianças matriculadas em unidades básicas de saúde (UBS) em dois períodos (1988-1989 e 2005-2006) e analisar a associação desses fatores com desnutrição, internação e óbito. MÉTODOS:Estudo de abordagem quantitativa, tipo coorte retrospectiva com amostra probabilística (n=414) de crianças menores de um ano matriculadas em duas UBSs do Embu (SP), em 2005-2006. Variáveis independentes: alto risco e presença de fatores de risco. Desfechos: evolução ponderal desfavorável, déficit nutricional, internação, óbito. Estatística: Qui-Quadrado e Odds Ratio. RESULTADOS: em 2005-2006, verificou-se: maior frequência de intercorrências neonatais e mães adolescentes; menor freqüência de desnutrição ou óbito de irmão < 5 anos; evolução ponderal desfavorável (1,6%); deficit nutricional (2,9%); IMC > 2z (17,9%); internações (21,8%); nenhum óbito. Baixo peso ao nascer associou-se à internação (OR=4,04;IC95%:1,35-12,04). CONCLUSÕES: Baixo peso ao nascer permanece, como importante fator de risco e a proporção de sobrepeso/obesidade indica necessidade de redirecionamento das ações de saúde da criança.

OBJECTIVE:To compare the frequency of risk factors in children attending basic health units (UBS) in two periods (1988-1989 and 2005-2006) and to analyze the association of these factors with malnutrition, hospitalization and death. METHODS: A retrospective study using a quantitative approach with a random cohort sample (n = 414) of children under one year of age, enrolled in two UBS of Embu (SP) in 2005-2006. Independent variables: high risk and presence of risk factors. Outcomes: unfavorable weight gain, malnutrition, hospitalization and death. Statistics: Chi-square and Odds Ratio. RESULTS: In 2005-2006, we found: a higher frequency of neonatal complications and adolescent mothers; lower rates of malnutrition or death of a sibling <5 years; unfavorable weight gain (1.6%); nutritional deficit (2.9%); BMI > 2z (17.9%); hospitalizations (21.8%); no deaths. Low birth weight was associated with hospitalization (OR = 4.04, 95% : 1,35-12, 04). CONCLUSIONS: Low birth weight remains an important risk factor and the proportion of overweight / obesity indicates a need for redirection of child health activities.

OBJETIVO: comparar las frecuencias de los factores de riesgo en niños matriculados en unidades básicas de salud (UBS) en dos períodos (1988-1989 y 2005-2006) y analizar la asociación de esos factores con desnutrición, internamiento y óbito. MÉTODOS: Estudio de abordaje cuantitativo, tipo cohorte retrospectivo con muestra probabilística (n=414) de niños menores de un año matriculados en dos UBSs de Embu (SP), en 2005-2006. Las variables independientes: alto riesgo y presencia de factores de riesgo. Desenlace: evolución ponderal desfavorable, déficit nutricional, internamiento, óbito. Estadística: Chi-Cuadrado y Odds Ratio. RESULTADOS: en 2005-2006, se verificó: mayor frecuencia de variaciones neonatales y madres adolescentes; menor frecuencia de desnutrición u óbito de hermano < 5 años; evolución ponderal desfavorable (1,6%); déficit nutricional (2,9%); IMC > 2z (17,9%); internamientos (21,8%); ningún óbito. Bajo peso al nacer se asoció al internamiento (OR=4,04;IC95%:1,35-12,04). CONCLUSIONES: Bajo peso al nacer permanece, como un importante factor de riesgo y la proporción de sobrepeso/obesidad indica la necesidad de redireccionamiento de las acciones de salud del niño.

Blood pressure control in hypertensive patients within family health program versus at primary healthcare units: analytical cross-sectional study / Controle da hipertensão arterial em pacientes no programa de saúde da família versus na unidade básica de saúde: estudo transversal analítico

CONTEXT AND OBJECTIVE: Hypertension is a public health problem due to its high prevalence and long-term cardiovascular complications. In Brazil in 2005, cardiovascular diseases were responsible for 28% of all deaths. Efforts are being made within primary care to achieve adequate hypertension control. The Family Health Program (FHP) has the aims of promoting quality of life and intervening in factors that put this at risk. The objective of this study was to evaluate the rate of blood pressure control among patients followed up at FHP units compared with those at primary healthcare units (PHUs). DESIGN AND SETTING: Analytical cross-sectional study in the municipality of Petrópolis, Rio de Janeiro, from January to December 2005. METHODS: Five hundred patients with a diagnosis of hypertension were included: 250 were being followed up at two FHP units and 250 at two PHUs. The diagnosis of hypertension was based on the Fourth Brazilian Hypertension Consensus, and the patients needed to have been under follow-up at the units for at least 12 months. Patients' blood pressure was considered to be under control if it was less than 140/90 mmHg at the last consultation. RESULTS: Blood pressure was under control in 29.2% (n = 73) at FHP units and 39.23% (n = 98) at PHUs (odds ratio = 0.64; confidence interval = 0.44-0.93; P = 0.024). CONCLUSION: Blood pressure control was better among patients followed up at PHUs than among those followed up at FHP units.

CONTEXTO E OBJETIVO: A hipertensão arterial (HA) é um problema de saúde pública por sua elevada prevalência e complicações em longo prazo. No Brasil as doenças cardiovasculares foram responsáveis, em 2005, por 28% do total de óbitos em geral. Esforços vêm sendo implementados na atenção básica para o seu adequado controle. O Programa de Saúde da Família tem o objetivo de promover qualidade de vida assim como intervir nos fatores que a coloquem em risco. O objetivo deste estudo foi verificar a taxa de controle da HA em pacientes acompanhados nas Unidades de Saúde da Família (USF) comparados com pacientes acompanhados nas Unidades Básicas de Saúde (UBS). TIPO DE ESTUDO E LOCAL: Estudo transversal analítico, no município de Petrópolis, Rio de Janeiro, entre janeiro e dezembro de 2005. MÉTODOS: Foram incluídos 500 pacientes com diagnóstico de HA, sendo 250 em acompanhamento em duas USF e 250 em duas UBS. O diagnóstico de HA foi baseado no IV Consenso Brasileiro de Hipertensão e os pacientes precisavam estar em acompanhamento nas Unidades por no mínimo 12 meses. Foram considerados controlados os pacientes que apresentaram níveis pressóricos inferiores a 140/90 mmHg na última consulta. RESULTADOS: A taxa de controle da pressão arterial foi de 29,2% (n = 73) nas USF e de 39,23% (n = 98) nas UBS (odds ratio = 0,64; intervalo de confiança = 0,44-0,93), P = 0,024). CONCLUSÃO: Foi observado melhor controle da pressão arterial nos pacientes acompanhados nas UBS quando comparados aos pacientes acompanhados nas USF.

[Overweight and obesity in prepubertal schoolchildren: the association with low birth weight and family antecedents of cardiovascular disease. Embu - metropolitan region of São Paulo, 2006]. / Sobrepeso e obesidade em escolares pré-púberes: associação com baixo peso ao nascer e antecedentes familiares para doença cardiovascular. Embu região metropolitana de São Paulo, 2006.

The aim was to determine the prevalence of overweight and obesity in schoolchildren and the association with birth weight and family antecedents of cardiovascular disease. This cross-sectional study used a probabilistic sample of 929 schoolchildren aged 6 to 10 years. The variables were: body mass index (BMI), birth weight and family antecedents of cardiovascular disease. The statistical analysis consisted of the chi-square test (Pearson) and odds ratio, as association measurements. Of the schoolchildren (54.6% of which were female), 14.4% and 13.3% were overweight and obese, respectively. Low birth weight was reported among 9.4% and family antecedents of cardiovascular disease among 35.2%. Overweight or obesity (BMI e" P85) was associated with the presence of family antecedents of cardiovascular disease (OR = 1.66; 95% CI 1.23-2.23) and male sex (OR = 1.37; 95%CI 1.02-1.83); there was no association with birth weight. The results indicate the need for preventive actions for children with family antecedents of cardiovascular disease.

Sobrepeso e obesidade em escolares pré-púberes: associação com baixo peso ao nascer e antecedentes familiares para doença cardiovascular. Embu região metropolitana de São Paulo, 2006 / Overweight and obesity in prepubertal schoolchildren: the association with low birth weight and family antecedents of cardiovascular disease. Embu - metropolitan region of São Paulo, 2006

O objetivo foi determinar a prevalência de sobrepeso e obesidade em escolares e a associação com baixo peso ao nascer e antecedentes familiares para doença cardiovascular. Estudo transversal que utilizou amostra probabilística de 929 escolares com idades de 6 a 10 anos. Variáveis: Índice de Massa Corpórea (IMC), peso ao nascer e antecedentes familiares para doença cardiovascular. Análise estatística: teste qui-quadrado (Pearson) e odds ratio como medidas de associação. 14,4 por cento e 13,3 por cento dos escolares (54,6 por cento do sexo feminino) apresentaram sobrepeso e obesidade, respectivamente. Baixo peso ao nascer foi referido em 9,4 por cento das crianças e a presença de antecedentes familiares para doença cardiovascular em 35,2 por cento. Sobrepeso ou obesidade (IMC maior ou igual a P85) associaram-se à presença de antecedentes familiares para doença cardiovascular (OR=1,66; IC95 por cento 1,23-2,23) e ao sexo masculino (OR=1,37; IC 95 por cento 1,02-1,83); não houve associação com o peso ao nascer. Os resultados indicam a necessidade de ações preventivas direcionadas às crianças com antecedentes familiares para doença cardiovascular.

The aim was to determine the prevalence of overweight and obesity in schoolchildren and the association with birth weight and family antecedents of cardiovascular disease. This cross-sectional study used a probabilistic sample of 929 schoolchildren aged 6 to 10 years. The variables were: body mass index (BMI), birth weight and family antecedents of cardiovascular disease. The statistical analysis consisted of the chi-square test (Pearson) and odds ratio, as association measurements. Of the schoolchildren (54.6 percent of which were female), 14.4 percent and 13.3 percent were overweight and obese, respectively. Low birth weight was reported among 9.4 percent and family antecedents of cardiovascular disease among 35.2 percent. Overweight or obesity (BMI e" P85) was associated with the presence of family antecedents of cardiovascular disease (OR = 1.66; 95 percent CI 1.23-2.23) and male sex (OR = 1.37; 95 percentCI 1.02-1.83); there was no association with birth weight. The results indicate the need for preventive actions for children with family antecedents of cardiovascular disease.

Seroprevalence of Helicobacter pylori infection among children of low socioeconomic level in São Paulo.

CONTEXT AND OBJECTIVE: Helicobacter pylori infection is mainly acquired during childhood, and is associated with significant morbidity in adults. The aim here was to evaluate the seroprevalence and risk factors of H. pylori infection among children of low socioeconomic level attended at a public hospital in São Paulo, Brazil. DESIGN AND SETTING: Cross-sectional study, among patients attended at an outpatient clinic. METHODS: 326 children were evaluated (150 boys and 176 girls; mean age 6.82 ± 4.07 years) in a cross-sectional study. Patients with chronic diseases or previous H. pylori treatment, and those whose participation was not permitted by the adult responsible for the child, were excluded. The adults answered a demographic questionnaire and blood samples were collected. The serological test used was Cobas Core II, a second-generation test. Titers > 5 U/ml were considered positive. RESULTS: H. pylori infection was diagnosed in 116 children (35.6%). Infected children were older than uninfected children (7.77 ± 4.08 years versus 5.59 ± 3.86 years; p < 0.0001). The seroprevalence increased from 20.8% among children aged two to four years, to 58.3% among those older than 12 years. There were no significant relationships between seropositivity and gender, color, breastfeeding, number of people in the home, number of rooms, bed sharing, living in a shantytown, maternal educational level, family income or nutritional status. In multivariate analysis, the only variable significantly associated with H. pylori seropositivity was age. CONCLUSION: Infection had intermediate prevalence in the study population, and age was associated with higher prevalence.

Seroprevalence of Helicobacter pylori infection among children of low socioeconomic level in São Paulo / Soroprevalência da infecção por Helicobacter pylori em crianças de baixo nível sócio-econômico em São Paulo

CONTEXT AND OBJECTIVE: Helicobacter pylori infection is mainly acquired during childhood, and is associated with significant morbidity in adults. The aim here was to evaluate the seroprevalence and risk factors of H. pylori infection among children of low socioeconomic level attended at a public hospital in São Paulo, Brazil. DESIGN AND SETTING: Cross-sectional study, among patients attended at an outpatient clinic. METHODS: 326 children were evaluated (150 boys and 176 girls; mean age 6.82 ± 4.07 years) in a cross-sectional study. Patients with chronic diseases or previous H. pylori treatment, and those whose participation was not permitted by the adult responsible for the child, were excluded. The adults answered a demographic questionnaire and blood samples were collected. The serological test used was Cobas Core II, a second-generation test. Titers > 5 U/ml were considered positive. RESULTS: H. pylori infection was diagnosed in 116 children (35.6 percent). Infected children were older than uninfected children (7.77 ± 4.08 years versus 5.59 ± 3.86 years; p < 0.0001). The seroprevalence increased from 20.8 percent among children aged two to four years, to 58.3 percent among those older than 12 years. There were no significant relationships between seropositivity and gender, color, breastfeeding, number of people in the home, number of rooms, bed sharing, living in a shantytown, maternal educational level, family income or nutritional status. In multivariate analysis, the only variable significantly associated with H. pylori seropositivity was age. CONCLUSION: Infection had intermediate prevalence in the study population, and age was associated with higher prevalence.

CONTEXTO E OBJETIVO: A infecção por Helicobacter pylori é adquirida principalmente na infância e é associada a morbidade significativa em adultos. O objetivo foi avaliar a soroprevalência de infecção por H. pylori bem como fatores de risco em crianças de baixo nível socioeconômico atendidas em um hospital público em São Paulo, Brasil. TIPO DE ESTUDO E LOCAL: Estudo transversal, realizado entre pacientes atendidos em ambulatório. MÉTODOS: Foram avaliadas 326 crianças (150 meninos e 176 meninas, idade: média 6,82 ± 4,07 anos) em estudo transversal. Foram excluídas aquelas com doenças crônicas, tratamento prévio de H. pylori e cujo responsável não consentiu participar do estudo. Os responsáveis responderam questionário demográfico e foi coletada uma amostra de sangue. O teste sorológico empregado foi o CobasCore II, exame de segunda geração, sendo considerados positivos títulos > 5 U/ml. RESULTADOS: Infecção por H. pylori foi diagnosticada em 116 (35,6 por cento). A idade dos pacientes infectados foi maior que a dos demais (7,77 ± 4,08 anos versus 5,59 ± 3,86 anos; p < 0,0001). A prevalência aumenta de 20,8 por cento entre dois e quatro anos de idade para 58,3 por cento entre maiores de 12 anos. Não houve relação significativa entre soropositividade e sexo, raça, aleitamento materno, número de pessoas ou de cômodos na casa, compartilhamento de camas, domicílio em favela, escolaridade materna, renda familiar ou estado nutricional. Na análise multivariada, a única variável significativamente associada a soropositividade foi idade. CONCLUSÃO: A infecção possui prevalência intermediária na população estudada, e a idade foi associada a maior prevalência.

Metabolic syndrome among prepubertal Brazilian schoolchildren.

This was a two-stage cross-sectional study that assessed metabolic syndrome and associated factors among prepubertal schoolchildren. In the first stage, nutritional status, blood pressure, personal (low birth weight) and family antecedents for cardiovascular disease (CVD) were collected. In the second stage, schoolchildren with at least one of these criteria participated: obesity, personal or family history. Metabolic syndrome (MS) was defined by ATP III and WHO definitions. Among 929 (6-10 year old) schoolchildren, 27.7% presented with overweight/obesity, 12.2% hypertension, and personal (9.4%) and family (35.3%) antecedents. 205 children finished the second stage. The frequencies of MS-ATP and MS-WHO were 9.3% and 1.9%. Among the obese, MS was present in 25.8% (ATP) and 5.2% (WHO). Children with normal weight presented: low HDL (23.6%), hyperglycaemia (3.6%), HOMA-IR (0.9%) and MS-ATP (0.9%). In conclusion, overweight/obesity was associated with metabolic syndrome in schoolchildren. It was found that children with normal weight with personal and/or family antecedents presented with HOMA-IR and MS-ATP.

The expression of vulnerability through infant mortality in the municipality of Embu / A expressão da vulnerabilidade na mortalidade infantil no município do Embu

CONTEXT AND OBJECTIVE: Infant mortality expresses a set of living, working and healthcare access conditions and opens up possibilities for adopting interventions to expand equity in healthcare. This study aimed to investigate vulnerability and the consequent differences in access to health services and occurrences of deaths among infants under one year of age in the municipality of Embu. DESIGN AND SETTING: This was a descriptive study in the municipality of Embu. METHODS: Primary data were collected through interviews with the families of children living in the municipality of Embu who died in the years 1996 and 1997 before reaching one year of age. Secondary data were obtained from death certificates. The variables collected related to living conditions, income, occupation, prenatal care, delivery and the healthcare provided for children. These data were compared with the results obtained from a study carried out in 1996. RESULTS: Statistically significant differences were found with regard to income, working without a formal employment contract and access to private health plans among the families of the children who died. There were also differences in access to and quality of prenatal care, frequency of low birth weight and neonatal intercurrences. CONCLUSIONS: The employment/unemployment situation was decisive in determining the degree of family stability and vulnerability to the occurrence of infant deaths, in addition to the conditions of access to and quality of healthcare services.

CONTEXTO E OBJETIVO: A mortalidade infantil expressa uma conjunção de fatores relacionados às condições de vida, trabalho e acesso aos serviços de saúde, e a identificação desses fatores pode contribuir para definição de intervenções em saúde. O objetivo deste trabalho foi analisar a expressão da vulnerabilidade e conseqüentes diferenças de acesso aos serviços de saúde e na ocorrência de óbitos em menores de um ano no município do Embu. TIPO DE ESTUDO E LOCAL: Estudo descritivo, no município de Embu. MÉTODOS: Foram coletados dados secundários (declarações de óbitos) e primários (entrevistas a famílias de crianças residentes do município do Embu, falecidas nos anos de 1996 e 1997, antes de completarem um ano). Variáveis estudadas foram relacionadas às condições de vida, renda e trabalho, à assistência pré-natal, ao parto e à atenção à saúde da criança, as quais foram comparadas com resultados obtidos em estudo realizado no ano de 1996. RESULTADOS: Verificaram-se diferenças estatisticamente significantes quanto a renda, trabalho sem carteira assinada e acesso a plano privado de saúde entre famílias de crianças que foram ao óbito. Verificaram-se, também, diferenças quanto ao acesso e à qualidade da assistência pré-natal, à freqüência de baixo peso ao nascer e a intercorrências neonatais. CONCLUSÕES: A situação de emprego/desemprego foi decisiva na determinação da estabilidade familiar, conferindo maior vulnerabilidade para ocorrência de óbitos infantis, somada às condições de acesso e à qualidade dos serviços de saúde.

Prophylaxis for iron deficiency anemia using ferrous sulfate among infants followed up at a primary healthcare unit in the municipality of Embu-SP (2003/2004).

CONTEXT AND OBJECTIVE: Iron deficiency anemia is an important public health problem in Brazil. In the municipality of Embu, a population study in 1996 found anemia prevalence of 68.5% among children aged one to two years. From these data, prescription of prophylactic ferrous sulfate was instituted in 1998 for children under two years old followed up within the children's healthcare program. After five years of intervention, the prevalence of anemia and associated factors were investigated among children aged 12 to 18 months to whom guidance for prophylactic ferrous sulfate use had been given. DESIGN AND SETTING: Cross-sectional study covering October 2003 to June 2004 at a primary healthcare unit in Embu. METHODS: A randomized sample of children aged 12 to 18 months to whom guidance for prophylactic ferrous sulfate use had been given was obtained. Hemoglobin was measured in capillary blood, using HemoCue apparatus. Hemoglobin < 11 g/100 dl was taken to indicate anemia. RESULTS: The sample comprised 118 children and anemia was found in 41.5%. There was no statistically significant association between anemia presence and the variables of sex, birth weight, neonatal intercurrences, chronic diseases, breastfeeding or iron supplementation use. There was a statistically significant association (p = 0.03) between anemia presence and per capita income, such that the higher the income was, the lower the prevalence of anemia was. CONCLUSION: The prophylaxis program against iron deficiency anemia did not achieve the expected results. New strategies must be considered in the light of the magnitude of the problem.

Risk factors associated with developmental abnormalities among high-risk children attended at a multidisciplinary clinic.

CONTEXT AND OBJECTIVE: Knowledge of risk factors associated with child development disorders is essential for delivering high-quality childcare. The objective here was to evaluate the relationships between risk factors and occurrences of developmental abnormalities among children attended at a reference clinic for children at risk of developmental abnormalities. DESIGN AND SETTING: Retrospective study at a multidisciplinary reference center, Embu, São Paulo. METHODS: All cases followed up for more than three months between 1995 and 2003 were reviewed. The risk factors assessed were low birth weight, gestational age, length of stay in neonatal ward, perinatal asphyxia, mothers age < 18 years, congenital infections, malformations and low mothers education level. Developmental abnormalities were defined according to developmental tests and assessments by the clinics professionals. The statistical analysis consisted of the chi-squared test for comparing categorical variables and a logistic regression model for multivariate analysis. RESULTS: 211 children were followed up for more than three months. Developmental abnormalities occurred in 111 (52.6%). Univariate analysis showed significant relationships between developmental abnormality and low birth weight, perinatal asphyxia, length of stay > 5 days, prematurity and mothers age 18 years and older. Low birth weight, history of perinatal asphyxia and mothers age continued to be significant in multivariate analysis. CONCLUSIONS: Special attention must be paid to the development of low birth weight infants and/or infants with histories of neonatal complications. Low birth weight is easily assessed and should be considered to be an important marker when defining guidelines for following up child development.